Journal
CLINICAL IMMUNOLOGY
Volume 183, Issue -, Pages 336-343Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2017.09.021
Keywords
B lymphocytes; Type 1 diabetes; TACI; FasR
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Funding
- NIH [5T32DK063688-12, U01 DK-070430]
- JDRF
- Human Metabolism Resource of the Institute for Diabetes, Obesity Metabolism
- [P30-CA016520]
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Although autoantibodies have been used for decades as diagnostic and prognostic markers in type 1 diabetes (T1D), further analysis of developmental abnormalities in B cells could reveal tolerance checkpoint defects that could improve individualized therapy. To evaluate B cell developmental progression in T1D, immunophenotyping was used to classify circulating B cells into transitional, mature naive, mature activated, and resting memory subsets. Then each subset was analyzed for the expression of additional maturation-associated markers. While the frequencies of B cell subsets did not differ significantly between patients and controls, some T1D subjects exhibited reduced proportions of B cells that expressed transmembrane activator and CAML interactor (TACI) and Fas receptor (FasR). Furthermore, some T1D subjects had B cell subsets with lower frequencies of class switching. These results suggest circulating B cells exhibit variable maturation phenotypes in T1D. These phenotypic variations may correlate with differences in B cell selection in individual T1D patients. (C) 2017 The Authors. Published by Elsevier Inc.
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