Journal
CLINICAL IMMUNOLOGY
Volume 183, Issue -, Pages 213-224Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2017.03.001
Keywords
Multiple sclerosis; Microbiome; CNS; Gut-brain axis; Microbial translocation; Intestinal permeability
Categories
Funding
- Acorda
- Bayer Pharmaceutical
- Biogen Idec
- EMD Serono
- Genzyme
- Novartis
- Questor
- Chugai
- Teva Neuroscience
- NIH NIAID Autoimmune Center of Excellence [UM1-AI110557]
- NIH NINDS [R01-NS080821]
- University of Michigan Neurology Department
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Individuals with multiple sclerosis (MS) have a distinct intestinal microbial community (microbiota) and increased low-grade translocation of bacteria from the intestines into the circulation. The observed change of intestinal bacteria in MS patients regulate immune functions involved in MS pathogenesis. These functions include: systemic and central nervous system (CNS) immunity (including peripheral regulatory T cell function), the blood-brain barrier (BBB) permeability and CNS-resident cell activity. This review discusses the MS intestinal microbiota implication on MS systemic- and CNS-immunopathology. We introduce the possible contributions of MS low-grade microbial translocation (LG-MT) to the development of MS, and end on a discussion on microbiota therapies for MS patients. (C) 2017 Elsevier Inc. All rights reserved.
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