Journal
ULTRASOUND IN MEDICINE AND BIOLOGY
Volume 43, Issue 12, Pages 2824-2833Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2017.08.937
Keywords
Focused ultrasound; Therapeutic ultrasound; Neuromodulation; Neurostimulation; Epidural cortical stimulation
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Ultrasound (US) is known to non-invasively stimulate and modulate brain function; however, the mechanism of action is poorly understood. This study tested US stimulation of rat motor cortex (100 W/cm(2), 200 kHz) in combination with epidural cortical stimulation. US directly evoked hindlimb movement. This response occurred even with short US bursts (3 ms) and had short latency (10 ms) and long refractory (3 s) periods. Unexpectedly, the epidural cortical stimulation hindlimb response was not altered during the 3-s refractory period of the US hindlimb response. This finding suggests that the US refractory period is not a general suppression of motor cortex, but rather the recovery time of a US-specific mechanism. (E-mail: dgulick@asu.edu) (C) 2017 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
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