Journal
ULTRASOUND IN MEDICINE AND BIOLOGY
Volume 43, Issue 7, Pages 1486-1493Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2017.03.012
Keywords
Low-intensity pulsed ultrasound; Spinal fusion; Calcitonin gene-related peptides
Funding
- National Natural Science Foundation of China [81301554]
- Natural Science Foundation of Shanghai [13 ZR1450200]
- Shanghai Municipal Health and Family Planning Commission [20154 Y0018]
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Low-intensity pulsed ultrasound (LIPUS) has been found to accelerate fracture healing. In this study, we analyzed the role of calcitonin gene-related peptide (CGRP) in a rat spinal fusion model treated with LIPUS. The results revealed that LIPUS significantly increases bone formation, and the process was coupled with elevated CGRP innervation. CGRP was located in fibrous tissue, closely surrounding the allograft and newly formed cartilage. The density of CGRP peaked at week 3 after surgery in both the control (non-LIPUS-treated) and LIPUS-treated groups. These results suggest that LIPUS might accelerate spinal fusion by promoting sensory nerve fiber innervation. (E-mail: weixianzhao@126.com) (C) 2017 World Federation for Ultrasound in Medicine & Biology.
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