Journal
ULTRASOUND IN MEDICINE AND BIOLOGY
Volume 43, Issue 11, Pages 2567-2575Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2017.07.010
Keywords
Contrast-enhanced ultrasonography; Papillary thyroid cancer; Metastatic; Cervical lymph nodes
Funding
- National Natural Science Foundation of China [81420108018, 81527803, 81271584]
- Main Scientific and Technological Project of Zhejiang Province of China [2013 C03044-1]
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The objective of this study was to prospectively evaluate the diagnostic accuracy of contrast-enhanced ultrasonography (CEUS) in differentiating between benign and metastatic cervical lymph nodes in patients with papillary thyroid cancer (PTC). Three hundred nineteen cervical lymph nodes (162 metastatic from PTC and 157 benign) were evaluated using conventional ultrasonography (US) and CEUS before biopsy or surgery. Metastatic lymph nodes more often manifested centripetal or asynchronous perfusion, hyper-enhancement, heterogeneous enhancement, perfusion defects and ring-enhancing margins than benign lymph nodes at pre-operative CEUS (all p values, 0.001). The area under the receiver operating characteristic curve (AUC) for the combination of conventional US and CEUS (0.983, 95% confidence interval [CI]: 0.971-0.994) was higher than that of conventional US alone (0.929, 95% CI: 0.899-0.958) and CEUS (0.911, 95% CI: 0.876-0.947). In conclusion, CEUS is a promising tool in conjunction with conventional US for the pre-operative prediction of metastatic cervical lymph nodes in patients with PTC. (C) 2017World Federation for Ultrasound in Medicine & Biology.
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