Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 91, Pages 12266-12269Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc06992h
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Funding
- National Natural Science Foundation of China [81402898]
- Youth Innovation Promotion Association CAS [2016257]
- CAS
- SANOFI-SIBS
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Cocrystallization of nifedipine (NFD) and isonicotinamide (INA) resulted in two monotropic cocrystal polymorphs. The thermodynamically more stable polymorph presents superior photostability compared to the other. Cocrystallization can be an efficient approach to address the stability deficit of dihydropyridine drugs.
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