4.7 Article

Taming photo-induced oxidation degradation of dihydropyridine drugs through cocrystallization

Journal

CHEMICAL COMMUNICATIONS
Volume 53, Issue 91, Pages 12266-12269

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc06992h

Keywords

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Funding

  1. National Natural Science Foundation of China [81402898]
  2. Youth Innovation Promotion Association CAS [2016257]
  3. CAS
  4. SANOFI-SIBS

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Cocrystallization of nifedipine (NFD) and isonicotinamide (INA) resulted in two monotropic cocrystal polymorphs. The thermodynamically more stable polymorph presents superior photostability compared to the other. Cocrystallization can be an efficient approach to address the stability deficit of dihydropyridine drugs.

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