Journal
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
Volume 273, Issue 7, Pages 1649-1661Publisher
SPRINGER
DOI: 10.1007/s00405-015-3631-8
Keywords
Ameloblastoma; Head and neck surgery; Clinical review; Genomics; Personalized medicine; SHH; BRAF
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Ameloblastoma is a rare odontogenic neoplasm of the mandible and maxilla, with multiple histologic variants, and high recurrence rates if improperly treated. The current mainstay of treatment is wide local excision with appropriate margins and immediate reconstruction. Here we review the ameloblastoma literature, using the available evidence to highlight the change in management over the past several decades. In addition, we explore the recent molecular characterization of these tumors which may point towards new potential avenues of personalized treatment.
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