4.5 Article

Esmolol reduces apoptosis and inflammation in early sepsis rats with abdominal infection

Journal

AMERICAN JOURNAL OF EMERGENCY MEDICINE
Volume 35, Issue 10, Pages 1480-1484

Publisher

W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ajem.2017.04.056

Keywords

Esmolol; Sepsis; Infection; Apoptosis; Inflammation; Cecal ligation and puncture

Funding

  1. Science and technology fund of Tianjin Municipal Health Bureau, China [2013KZ091]
  2. Science Foundation of Tianjin Medical University, China [2014KYQ10]

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Background: Esmolol is a highly selective beta 1 receptor blocker with various effects such as slowing heart rate, lowering blood pressure and reducing myocardial oxygen consumption. However, few studies have reported the use of beta blockers in sepsis with multiple organ dysfunctions. This study aimed to investigate the effects of esmolol on reducing apoptosis and inflammation in early sepsis rats with abdominal infection. Methods: Rats were randomly divided into sham operation group, sepsis group, antibiotic group, Esmolol + antibiotic group with low, median and high dose Esmolol (L group, M group and H group). Values between two or more groups were compared by independent t-tests. Results: In the liver and kidney, we found inflammatory infiltration in sepsis group while pathological aspects reduced in L, M and H groups. Bcl-2 mRNA and protein levels increased while Bax mRNA and protein levels decreased in the liver and kidney of L, M and H groups. Serum IL-6, HMGB-1 and TNF-alpha levels decreased but IL-10 level increased in L, M and H groups, compared to sepsis group. Compared to sepsis and antibiotic groups, the levels of myocardial enzymes were lower in L, M and H groups. Conclusion: The administration of esmolol in early sepsismay reduce inflammation, inhibit apoptosis and protect key organs. (C) 2017 Elsevier Inc. All rights reserved.

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