Journal
CHINESE JOURNAL OF ORGANIC CHEMISTRY
Volume 37, Issue 11, Pages 2818-2840Publisher
SCIENCE PRESS
DOI: 10.6023/cjoc201705022
Keywords
phosphoramidates: prodrugs; nucleoside and nucleotide; antiviral drug; phosphate and phosphonate; ProTide
Categories
Funding
- Introduction of Innovative RAMP
- D Team Program of Guangdong Province [201301Y0105381261]
- State Key Laboratory of Anti-Infective Drug Development (Sunshine Lake Pharma Co. Ltd) [2015DQ780357]
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This review provides the brief history for the development and advances of ProTide strategies in the field of antiviral and anticancer pharmaceutical development. A summary is provided for the synthesis of nucleoside phosphoramidates, recent breakthroughs in the stereoselective assembly of chiral prodrugs and its application. This technology is extremely useful and has simplified innovative drug design of phosphorous-containing prodrugs. Simplifying such structural modification may create a new avenue of competition in the invention of new medicines from the parent drug.
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