Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 92, Pages 12406-12409Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc08162f
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Funding
- National Natural Science Foundation of China [21475059, 21527809, 21775069]
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We developed a dual-target theranostic F-671, which could exhibit synergetic anticancer effects for inhibiting the activities of glutathione S-transferase and the accumulation of hypoxia inducible factor-1 alpha. F-671 undergoes self-immolative cleavage when exposed to GSTP1-1 in live cancer cells, facilitating the visualization of molecule release and distribution, as well as confirming the autophagy-induced apoptosis.
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