Journal
TUMORI JOURNAL
Volume 103, Issue 3, Pages 242-248Publisher
SAGE PUBLICATIONS LTD
DOI: 10.5301/tj.5000601
Keywords
Circulating tumor cells; Clinical characteristics; Prognosis; Progression-free survival; Small-cell lung cancer
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Funding
- Xinjiang Production and Construction Corps Science and Technology Program Special Fund [2012BA042]
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Background: This study investigated the correlation of the presence of circulating tumor cells (CTCs) with clinical characteristics, and the predictive value of CTCs for progression-free survival (PFS) in patients with small-cell lung cancer (SCLC). Methods: Samples were obtained from 42 patients with SCLC before and after the first cycle of chemotherapy. CTCs were quantitated by negative immunomagnetic enrichment and immunocytochemistry using anti-CD45 and anti-pancytokeratin antibodies. Results: CTCs were positive (>= 2) in 76.19% of patients with SCLC and negative in the control group. The presence of CTCs was positively correlated with 6 clinical characteristics. PFS was 6.055 and 10.670 months for patients with >= 2 and <2 CTCs/7.5 mL of blood before chemotherapy; after chemotherapy PFS was 4.862 and 10.535 months, respectively. Conclusions: This study showed that both baseline CTC numbers and the change in CTC numbers after 1 cycle of chemotherapy are significant prognostic factors of PFS for SCLC.
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