Journal
TUMOR BIOLOGY
Volume 39, Issue 2, Pages -Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1010428317692205
Keywords
UHRF1; epigenetics; biomarker; resistance; molecular regulation; natural polyphenols
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Funding
- University Grants Commission, India [43-72/2014]
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UHRF1 is a master regulator of epigenome as it coordinates DNA methylation and histone modifications. Compelling evidence suggests a strong link between UHRF1 overexpression and tumorigenesis, substantiating its ability to act as a potential biomarker for cancer diagnosis and prognosis. UHRF1 also mediates repair of damaged DNA that makes cancer cells resistant toward cytocidal drugs. Hence, understanding the molecular mechanism of UHRF1 regulation would help in developing cancer therapeutics. Natural compounds have shown applicability to downregulate UHRF1 leading to growth arrest and apoptosis in cancer cells.
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