Journal
CURRENT OPINION IN BIOMEDICAL ENGINEERING
Volume 4, Issue -, Pages 106-115Publisher
ELSEVIER
DOI: 10.1016/j.cobme.2017.10.005
Keywords
Synthetic biology; RNA engineering; Medical diagnostics; Gene regulation; Translational medicine
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Funding
- National Institute of General Medical Sciences of the National Institutes of Health [T32GM008412]
- Stanford Vice Provost for Graduate Education EDGE-STEM Fellowship
- National Institutes of Health
- Human Frontiers Science Research Program
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Emergent RNA technologies employ sequence and structural information to perform a diversity of biological functions. Synthetic RNA molecules have been developed for a wide array of applications, including genetic regulation, environmental sensing, and diagnostics devices. Recent advances in chemical synthesis and computational design of RNA have enhanced our ability to program novel functions and expand upon current biomedical applications for therapeutics and diagnostics. In this review, we highlight recent advances in synthetic RNA devices that have been engineered for biomedical systems, while addressing the current limitations and challenges of translating these engineered functional RNAs to clinical applications.
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