Journal
EMERGING INFECTIOUS DISEASES
Volume 23, Issue 12, Pages 2023-2029Publisher
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2312.170883
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Funding
- University of Fribourg
- Animal Health and Welfare ERA-Net project, Switzerland
- Office Federal de la Sante Publique, Bern, Switzerland [16009294]
- Fundacao para a Ciencia e a Tecnologia, Portugal [PTDC/DTP-EPI/0842/2014]
- Novartis Foundation for Medical-Biological Research
- Fundação para a Ciência e a Tecnologia [PTDC/DTP-EPI/0842/2014] Funding Source: FCT
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The mcr-1 (mobile colistin resistance 1) gene, which encodes phosphoethanolamine transferase, has been recently identified as a source of acquired resistance to polymyxins in Escherichia coli. Using the SuperPolymyxin selective medium, we prospectively screened 100 pigs at 2 farms in Portugal for polymyxin-resistant Enterobacteriaceae and recovered 98 plasmid-mediated MCR-1-producing isolates. Most isolates corresponded to nonclonally related E. coli belonging to many sequence types; we also found 2 Klebsiella pneumoniae sequence types. The mcr-1 gene was carried on IncHI2 or IncP plasmid backbones. Our finding of a high rate of MCR-1 producers on 2 pig farms in Portugal highlights the diffusion of that colistin-resistance determinant at the farm level. The fact that the pigs received colistin as metaphylaxis in their feed during the 6 weeks before sampling suggests selective pressure.
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