Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 74, Issue 23, Pages 4259-4268Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-017-2643-5
Keywords
Periostin; fas 1 family; Matricellular protein; Alternative splicing; Proteinase cleavage
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Although many studies have described the role of periostin in various diseases, the function of the periostin protein structures derived from alternative splicing and proteinase cleavage at the C-terminal remain unknown. Further experiments revealing the protein structures that are highly related to diseases are essential to understand the function of periostin in depth, which would accelerate its clinical application by establishing new approaches for curing intractable diseases. Furthermore, this understanding would enhance our knowledge of novel functions of periostin related to stemness and response to mechanical stress.
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