Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Volume 1862, Issue 12, Pages 1534-1545Publisher
ELSEVIER
DOI: 10.1016/j.bbalip.2017.09.002
Keywords
Steryl ester synthase; Steryl ester hydrolase; Lipid droplet; Sterol homeostasis
Funding
- Austrian Science Fund (FWF) [P23029, W901]
- Austrian Science Fund (FWF) [P 27346] Funding Source: researchfish
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Sterols are essential lipids of all eukaryotic cells, appearing either as free sterols or steryl esters. Besides other regulatory mechanisms, esterification of sterols and hydrolysis of steryl esters serve to buffer both an excess and a lack of free sterols. In this review, the esterification process, the storage of steryl esters and their mobilization will be described. Several model organisms are discussed but the focus was set on mammals and the yeast Saccharomyces cerevisiae. The contribution of imbalanced cholesterol homeostasis to several human diseases, namely Wolman disease, cholesteryl ester storage disease, atherosclerosis and Alzheimer's disease, Niemann-Pick type C and Tangier disease is described.
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