Journal
CHINESE JOURNAL OF NATURAL MEDICINES
Volume 15, Issue 12, Pages 899-904Publisher
CHINESE JOURNAL NATURAL MEDICINES
DOI: 10.1016/S1875-5364(18)30005-0
Keywords
Gardenoside; Geniposide; Crocin; Inflammation; Memory; Gardenia jasminoides; Neurodegenerative diseases
Funding
- programs of Thousand Talents Program Research Park (Jiangsu, China)
- Provincial Innovation and Entrepreneurial Talent, Jiangsu, China
- Development of Society and Technology (Kunshan City, Jiangsu, China)
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Herbal extracts have been extensively used worldwide for their application on memory improvement, especially among aged and memory-deficit populations. In the present study, the memory loss induced by human Abeta protein over-expression in fruit-fly Alzheimer's disease (AD) model was rescued by multiple extracts from Gardenia jasminoides. Three extracts that rich with gardenia yellow, geniposide, and gardenoside components showed distinct rescue effect on memory loss. Further investigation on adding gardenoside into a formula of Ganoderma lucidum, Panax notoginseng and Panax ginseng (GPP) also support its therapeutic effects on memory improvement. Interestingly, the application of GPP and gardenoside did not alter the accumulation of Abeta proteins but suppressed the expression of immune-related genes in the brain. These results revealed the importance and relevancy of anti-inflammation process and the underlying mechanisms on rescuing memory deficits, suggesting the potential therapeutic use of the improved GPP formulation in improving cognition in defined population in the future.
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