Journal
COORDINATION CHEMISTRY REVIEWS
Volume 352, Issue -, Pages 499-516Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2017.05.011
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- Australian Research Council
- Australian National Health and Medical Research Council
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Positron emission tomography (PET) is a medical diagnostic imaging technique that requires administration of a (3'-emitting radiotracer to a patient. Metal-based PET radiotracers have become increasingly used in both preclinical and clinical settings in recent years, particularly those incorporating the remitting isotopes of copper, gallium and zirconium. The synthesis of metal-based PET imaging agents with high radiochemical yields and purities requires careful consideration of the speciation of the metal ions in the presence of aqueous buffers and the physiological environment. This review discusses aspects of copper, gallium and zirconium metal ion speciation of relevance to the design and synthesis of radiopharmaceuticals. (C) 2017 Elsevier B.V. All rights reserved.
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