Journal
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
Volume 17, Issue 12, Pages -Publisher
SPRINGER
DOI: 10.1007/s11910-017-0802-6
Keywords
Microbiota; Microbiome; Gut-brain axis; Neurodegenerative diseases; Parkinson's disease; Alzheimer's disease; Probiotics; Antibiotics; Fecal microbiota transplantation
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Purpose of Review The purposes of this review were as follows: first, to provide an overview of the gut microbiota and its interactions with the gut and the central nervous system (the microbiota-gut-brain axis) in health, second, to review the relevance of this axis to the pathogenesis of neurodegenerative diseases, such as Parkinson's disease, and, finally, to assess the potential for microbiota-targeted therapies. Recent Findings Work on animal models has established the microbiota-gut-brain axis as a real phenomenon; to date, the evidence for its operation in man has been limited and has been confronted by considerable logistical challenges. Animal and translational models have incriminated a disturbed gut microbiota in a number of CNS disorders, including Parkinson's disease; data from human studies is scanty. While a theoretical basis can be developed for the use of microbiota-directed therapies in neurodegenerative disorders, support is yet to come from high-quality clinical trials. Summary In theory, a role for the microbiota-gut-brain axis is highly plausible; clinical confirmation is awaited.
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