Journal
BIOMATERIALS
Volume 148, Issue -, Pages 16-30Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2017.09.017
Keywords
Nanomaterials; Cancer immunotherapy; Cancer vaccine; Tumor microenvironment
Funding
- NIH [CA198999, DK100664]
- Eshelman Institute for Innovation
- National Natural Science Foundation of China [51673185]
- China Scholarship Council
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Cancer immunotherapy is quickly growing to be the fourth most important cancer therapy, after surgery, radiation therapy, and chemotherapy. Immunotherapy is the most promising cancer management strategy because it orchestrates the body's own immune system to target and eradicate cancer cells, which may result in durable antitumor responses and reduce metastasis and recurrence more than traditional treatments. Nanomaterials hold great promise in further improving the efficiency of cancer immunotherapy - in many cases, they are even necessary for effective delivery. In this review, we briefly summarize the basic principles of cancer immunotherapy and explain why and where to apply nano materials in cancer immunotherapy, with special emphasis on cancer vaccines and tumor microenvironment modulation. (C) 2017 Elsevier Ltd. All rights reserved.
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