Journal
CARBOHYDRATE POLYMERS
Volume 177, Issue -, Pages 135-143Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2017.08.131
Keywords
Chitosan; Kaolin; Porous microspheres; Hemostatic material
Categories
Funding
- Social Development of Instructive Program of Fujian Province [2017Y0025]
- National Key Basic Research Program of China [2015CB352006]
- Fujian Provincial Health Education Joint Research Project [WKJ2016-2-29]
- Natural Science Foundation of Fujian Province [2017J01408]
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The hemostatic performance of chitosan was greatly improved by blending it with kaolin to fabricate porous composite microspheres (CSMS-K) through inverse emulsion method combining with thermally induced phase separation. The CSMS-K had high amount of interior and surface pores. The synergetic hemostatic competence of chitosan and kaolin components made the hemostatic efficacy of CSMS-K superior to chitosan porous microspheres (CSMS). The hemostatic time of CSMS-K3 in the rat tail amputation and liver laceration models was down to respective 120 and 99 s from 183 and 134 s of CSMS, and the blood loss of CSMS-K3 was respectively 65% and 36% of that of CSMS in the rat tail amputation and liver laceration models. The whole blood clotting kinetics proved that CSMS-K3 formed larger blood clots than CSMS and Celox within a same time period. Our results suggested that the CSMS-K is a potential quick pro-coagulant agent for traumatic hemorrhaging control.
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