Journal
BIOTECHNOLOGY ADVANCES
Volume 35, Issue 8, Pages 1022-1031Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2017.09.002
Keywords
Monoterpenes; Chassis engineering; Cytotoxicity alleviation; Enzyme engineering
Categories
Funding
- National Natural Science Foundation of China [21621004, 21390203]
- Ministry of Science and Technology of China (973 Program) [2014CB745100]
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Microbial production of monoterpenes is often limited by their cytotoxicity and in vivo conversion. Therefore, alleviating cytotoxicity and reducing conversion by chassis engineering are highly desirable. On the other hand, engineering key enzymes is also critical for improving monoterpenes production through facilitating the biosynthesis process. Here we critically review recent advances in cytotoxicity alleviation, reducing in vivo conversion, selecting geranyl diphosphate synthase and engineering monoterpene synthases. These achievements would lead to the development of superior chassis with improved tolerance to cytotoxicity and rationally tailored metabolites profiles to improve titer, yield and productivity for the production of monoterpenes by microbial cells.
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