Journal
TRENDS IN PLANT SCIENCE
Volume 22, Issue 6, Pages 512-526Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tplants.2017.03.009
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [STA653, SPP1530]
- Office of Competitive Research Grant Program from King Abdullah University of Science and Technology (KAUST) [CRG3-62140383]
- German National Academic Foundation
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RNA-protein interaction is an important checkpoint to tune gene expression at the RNA level. Global identification of proteins binding in vivo to mRNA has been possible through interactome capture - where proteins are fixed to target RNAs by UV crosslinking and purified through affinity capture of polyadenylated RNA. In Arabidopsis over 500 RNA-binding proteins (RBPs) enriched in UV-crosslinked samples have been identified. As in mammals and yeast, the mRNA interactomes came with a few surprises. For example, a plethora of the proteins caught on RNA had not previously been linked to RNA-mediated processes, for example proteins of intermediary metabolism. Thus, the studies provide unprecedented insights into the composition of the mRNA interactome, highlighting the complexity of RNA-mediated processes.
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