Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 38, Issue 3, Pages 226-256Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2016.11.009
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Funding
- West Virginia School of Osteopathic Medicine Faculty Startup Funding from Southwest Medical University, Lanzhou, Sichuan, China
- Distinguished Professor Research Startup Funding from Southwest Medical University, Lanzhou, Sichuan, China
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Heat shock proteins (HSPs) constitute a large family of proteins involved in protein folding and maturation whose expression is induced by heat shock or other stressors. The major groups are classified based on their molecular weights and include HSP27, HSP40, HSP60, HSP70, HSP90, and large HSPs. HSPs play a significant role in cellular proliferation, differentiation, and carcinogenesis. In this article we comprehensively review the roles of major HSPs in cancer biology and pharmacology. HSPs are thought to play significant roles in the molecular mechanisms leading to cancer development and metastasis. HSPs may also have potential clinical uses as biomarkers for cancer diagnosis, for assessing disease progression, or as therapeutic targets for cancer therapy.
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