Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 38, Issue 6, Pages 541-555Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2017.03.010
Keywords
-
Categories
Funding
- RTG [1331]
- BMBF
- Doerenkamp-Zbinden Foundation
- KoRS Chemical Biology
- Collaborative Research Center 969 'Chemical and Biological Principles of Cellular Proteostasis'
- Deutsche Forschungsgemeinschaft
Ask authors/readers for more resources
The neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes a Parkinson's disease (PD)-like syndrome by inducing degeneration of nigrostriatal dopaminergic neurons. Studies of the MPTP model have revealed the pathomechanisms underlying dopaminergic neurodegeneration and facilitated the development of drug treatments for PD. In this review, we provide an update on MPTP bioactivation and biodistribution, reconcile the distinct views on energetic failure versus reactive oxygen species (ROS) formation as main drivers of MPTP-induced neurodegeneration, and describe recently identified intrinsic features of the nigrostriatal system that make it particularly vulnerable to MPTP. We discuss these new perspectives on the endogenous tipping points of tissue homeostasis and the drivers responsible for vicious cycles in relation to their relevance for the development of novel intervention strategies for PD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available