Journal
BIOTECHNOLOGY ADVANCES
Volume 35, Issue 8, Pages 1040-1048Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2017.09.007
Keywords
Succinate; Escherichia coli; Metabolic engineering; CO2 fixation; Fermentation
Categories
Funding
- National Natural Science Foundation for Distinguished Young Scholars (NSFC) [21625602]
- National Natural Science Foundation of China (NSFC) [21376066, 81503112, 21506049, 31570054]
- Hubei Provincial Science and Technology Innovation Major Project [CXZD2017000283]
- Hubei Provincial Natural Science Foundation for Innovative Research Team [2015CFA013]
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As an important intermediate feedstock, succinate is termed as one of the 12 bio-based platform chemicals. To improve its fermentative production, various strategies have been developed, but challenges are still ahead for succinate biosynthesis to be cost-competitive. In this article, strategies for succinate production through metabolic engineering of Escherichia coli are critically reviewed, with a focus on engineering by-product formation and CO2 fixation, substrate utilization, reducing power balance, metabolic evolution and transcriptional regulation, which provide insights for the current state of succinate production and perspectives for further research for more efficient and economical production of bio-based succinate.
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