Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 38, Issue 5, Pages 473-488Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2017.02.003
Keywords
-
Categories
Funding
- NIAID NIH HHS [R01 AI052453, R37 AI052453, R01 AI093451, U01 AI124316] Funding Source: Medline
- NICHD NIH HHS [P50 HD090259, U54 HD090259] Funding Source: Medline
Ask authors/readers for more resources
The rise of multidrug-resistant pathogens and the dearth of new antibiotic development place an existential strain on successful infectious disease therapy. Breakthrough strategies that go beyond classical antibiotic mechanisms are needed to combat this looming public health catastrophe. Reconceptualizing antibiotic therapy in the richer context of the host-pathogen interaction is required for innovative solutions. By defining specific virulence factors, the essence of a pathogen, and pharmacologically neutralizing their activities, one can block disease progression and sensitize microbes to immune clearance. Likewise, host-directed strategies to boost phagocyte bactericidal activity, enhance leukocyte recruitment, or reverse pathogen-induced immunosuppression seek to replicate the success of cancer immunotherapy in the field of infectious diseases. The answer to the threat of multidrug-resistant pathogens lies 'outside the box' of current antibiotic paradigms.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available