Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 38, Issue 11, Pages 967-981Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2017.07.006
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Funding
- Ministry of Science and Technology of Taiwan [MOST103-2320-B-182-027-MY3, MOST-104-2320-B-030-009]
- Chang Gung Memorial Hospital at Linkou [CMRPDm1E0072, CMRPD1F0121, QZRPD120]
- Primordia Institute of New Sciences and Medicine
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Plants and mushrooms are used for medicinal purposes and the screening of molecules possessing biological activities. A single plant or mushroom may produce both stimulatory and inhibitory effects on immune cells, depending on experimental conditions, but the reason behind this dichotomy remains obscure. We present here a large body of experimental data showing that water extracts of plants and mushrooms usually activate immune cells, whereas ethanol extracts inhibit immune cells. The mode of extraction of plants and mushrooms may thus determine the effects produced on immune cells, possibly due to differential solubility and potency of stimulatory and inhibitory compounds. We also examine the possibility of using such plant and mushroom extracts to treat immune system disorders.
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