Journal
TRENDS IN PARASITOLOGY
Volume 33, Issue 9, Pages 662-664Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2017.07.004
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The pyrazolopyridine KDU731 is a promising drug candidate for treatment of diarrhea caused by Cryptosporidium in young children in the resource-limited world. KDU731, a PI (4) kinase inhibitor, blocks Cryptosporidium infection in vitro and in vivo in immunocompromised mice and dramatically reduces oocyst shedding, diarrhea, and dehydration in neonatal calves.
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