Journal
TRENDS IN NEUROSCIENCES
Volume 40, Issue 9, Pages 536-554Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2017.07.001
Keywords
-
Categories
Funding
- Bettencourt Schuller Foundation (Paris, France)
- AMU-AMIdex (Marseille France)
- Simons Foundation for Autism (USA)
Ask authors/readers for more resources
In physiological conditions, adult neurons have low intracellular Cl- [(Cl-) I] levels underlying the gamma-aminobutyric acid (GABA) ergic inhibitory drive. In contrast, neurons have high (Cl (-)) I levels and excitatory GABA actions in a wide range of pathological conditions including spinal cord lesions, chronic pain, brain trauma, cerebrovascular infarcts, autism, Rett and Down syndrome, various types of epilepsies, and other genetic or environmental insults. The diuretic highly specific NKCC1 chloride importer antagonist bumetanide (PubChem CID: 2461) efficiently restores low (Cl-) I levels and attenuates many disorders in experimental conditions and in some clinical trials. Here, I review the mechanisms of action, therapeutic effects, promises, and pitfalls of bumetanide.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available