Journal
TRENDS IN MICROBIOLOGY
Volume 25, Issue 8, Pages 614-623Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2017.02.012
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Funding
- Royal Society-Science Foundation Ireland University Research Fellowship
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Antagonistic coevolution (AC) between bacteria and bacteriophages plays a key role in driving and maintaining microbial diversity. Consequently, AC is predicted to affect all levels of biological organisation, from the individual to ecosystem scales. Nonetheless, we know nothing about bacteria-bacteriophage AC in perhaps the most important and clinically relevant microbial ecosystem known to humankind - the human gut microbiome. In this opinion piece I review current research on bacteria-phage AC in in vitro and natural populations of microbes. I then examine the evidence and discuss the potential role of AC in driving observed patterns of intra-and interindividual variation in the gut microbiome together with detailing the potential functional consequences of such AC-driven microbial variation for human health and disease.
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