Journal
TRENDS IN MICROBIOLOGY
Volume 25, Issue 9, Pages 756-767Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2017.05.007
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Funding
- National Institutes of Health: Centers of Excellence for Translational Research (CETR) [1U19AI109713 NIH/NIAID]
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Bacteria are capable of performing a number of biotransformations that may activate or deactivate xenobiotics. Recent efforts have utilized metabolomics techniques to study the fate of small-molecule antibacterials within the targeted organism. Examples involving Mycobacterium tuberculosis are reviewed and analyzed with regard to the insights they provide as to both activation and deactivation of the antibacterial. The studies, in particular, shed light on biosynthetic transformations performed by M. tuberculosis while suggesting avenues for the evolution of chemical tools, highlighting potential areas for drug discovery, and mechanisms of approved drugs. A two-pronged approach investigating the metabolism of antibacterials within both the host and bacterium is outlined and will be of value to both the chemical biology and drug discovery fields.
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