Journal
TRENDS IN MICROBIOLOGY
Volume 25, Issue 3, Pages 229-241Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2016.11.009
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Funding
- Deutsche Forschungsgemeinschaft [AD131/3-3, AD131/4-1]
- Bundesministerium fuer Bildung and Forschung (NGFNplus) [PIM-01GS0802-3]
- Wilhelm Sander-Stiftung [2009.046.1+2]
- Helmholtz Zentrum Munchen - German Research Center for Environmental Health (GmbH)
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During a long history of coevolution, herpesviruses have reached a fine-tuned balance with their hosts, allowing them to successfully persist and spread to new hosts without causing too much damage. Only under certain circumstances, as in neonates or immunocompromised individuals, they may cause serious diseases. The delicate balance between herpesviruses and their hosts results from interactions of a great variety of viral and cellular factors which together shape the tropism for a particular host, tissue, or cell. Understanding these interactions will provide insight into the viral life cycle and cell biology in general. Moreover, it will also facilitate comprehension of herpesvirus pathogenesis, enabling the development of new strategies to combat herpesviruses in cases where they cause disease.
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