Journal
TRENDS IN MICROBIOLOGY
Volume 25, Issue 11, Pages 906-918Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2017.05.008
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Funding
- French Region Centre-Val de Loire [2015-00099232]
- European funding in Region Centre-Val de Loire (FEDER) [2016-00110366]
- CNRS LIA [1047]
- National Institutes of Health [R01 AI116453]
- Brazilian CAPES/PVE [030490/2013-01]
- CNPq/PDE [201452/2015-4]
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The STING (Stimulator of Interferon Genes) protein connects microorganism cytosolic sensing with effector functions of the host cell by sensing directly cyclic dinucleotides (CDNs), originating from pathogens or from the host upon DNA recognition. Although STING activation favors effective immune responses against viral infections, its role during bacterial diseases is controversial, ranging from protective to detrimental effects for the host. In this review, we summarize important features of the STING activation pathway and recent highlights about the role of STING in bacterial infections by Chlamydia, Listeria, Francisella, Brucella, Shigella, Salmonella, Streptococcus, and Neisseria genera, with a special focus on mycobacteria.
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