Journal
TRENDS IN IMMUNOLOGY
Volume 38, Issue 11, Pages 805-816Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2017.07.010
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Funding
- Takeda Science Foundation
- MEXT/JSPS of Japan [15H05703, 16H06228, 17K19545]
- Grants-in-Aid for Scientific Research [17K19545, 16H06228, 15H05703] Funding Source: KAKEN
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T cells undergo positive and negative selection in the thymic cortex and medulla, respectively. A promiscuous expression of a wide array of self-antigens in the thymus is essential for the negative selection of self-reactive T cells and the establishment of central tolerance. Aire was originally thought to be the exclusive factor regulating the expression of tissue-restricted antigens, but Fezf2 recently emerged as a critical transcription factor in this regulatory activity. Fezf2 is selectively expressed in thymic medullary epithelial cells, regulates a large number of tissue-restricted antigens and suppresses the onset of autoimmune responses. Here, we discuss novel findings on the transcriptional mechanisms of tissue restricted-antigen expression in the medullary thymic epithelial cells and its effects on T cell selection.
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