Journal
TRENDS IN IMMUNOLOGY
Volume 38, Issue 10, Pages 758-767Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2017.07.004
Keywords
-
Categories
Funding
- NIAID NIH HHS [R21 AI112258, R01 AI109799, R21 AI122092] Funding Source: Medline
Ask authors/readers for more resources
NOD1 and NOD2 are pattern recognition receptors of the innate immune system with well-established roles in sensing fragments of bacterial peptidoglycan. In addition to their role as microbial sensors, recent evidence indicates that nucleotide-binding oligomerization domains (NODs) can also recognize a broader array of danger signals. Indeed, recent work has expanded the roles of NOD1 and NOD2 to encompass not only sensing of infections with viruses and parasites but also perceiving perturbations of cellular processes such as regulation of the actin cytoskeleton and maintenance of endoplasmic reticulum homeostasis. This review will comment on recent progress and point out emerging questions in these areas.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available