Journal
TRENDS IN IMMUNOLOGY
Volume 38, Issue 11, Pages 793-804Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2017.07.007
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Funding
- National Multiple Sclerosis Society [RG5019A]
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [R01AI113903]
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Mechanisms of tolerance initiated in the thymus are indispensable for establishing immune homeostasis, but they may not be sufficient to prevent tissue-specific autoimmune diseases. In the periphery, dendritic cells (DCs) play a crucial tolerogenic role, extending the maintenance of immune homeostasis and blocking autoimmune responses. We review here these essential roles of DCs in orchestrating mechanisms of peripheral T cell tolerance as determined by targeted delivery of defined antigens to DCs in vivo in combination with various genetic modifications of DCs. Further, we discuss how DC functions empowered by specific delivery of T cell antigens could be harnessed for tolerance induction in clinical settings.
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