Journal
TRENDS IN GENETICS
Volume 33, Issue 5, Pages 349-363Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2017.03.005
Keywords
-
Categories
Funding
- National Institutes of Health [F31HD089591, R01GM112801-02]
Ask authors/readers for more resources
The aurora kinases (AURKs) comprise an evolutionarily conserved family of serine/threonine kinases involved in mitosis and meiosis. While most mitotic cells express two AURK isoforms (AURKA and AURKB), mammalian germ cells also express a third, AURKC. Although much is known about the functions of the kinases in mitosis, less is known about how the three isoforms function to coordinate meiosis. This review is aimed at describing what is known about the three isoforms in female meiosis, the similarities and differences between kinase functions, and speculates as to why mammalian germ cells require expression of three AURKs instead of two.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available