Journal
TRENDS IN GENETICS
Volume 33, Issue 10, Pages 760-769Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2017.07.010
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Funding
- NCATS NIH HHS [UL1 TR001878] Funding Source: Medline
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The circadian clock directs many aspects of metabolism, to separate in time opposing metabolic pathways and optimize metabolic efficiency. The master circadian clock of the suprachiasmatic nucleus synchronizes to light, while environmental cues such as temperature and feeding, out of phase with the light schedule, may synchronize peripheral clocks. This misalignment of central and peripheral clocks may be involved in the development of disease and the acceleration of aging, possibly in a gender-specific manner. Here we discuss the interplay between the circadian clock and metabolism, the importance of the microbiome, and how they relate to aging.
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