Journal
TRENDS IN GENETICS
Volume 33, Issue 12, Pages 897-898Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2017.10.003
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Funding
- National Institutes of Health [1DP2HD080352-01]
- New York State Stem Cell Science Board [C029156]
- Tri-Institutional Stem Cell Initiative
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Artificial chromosomes are useful in making functional vectors for very large genes, studying chromosome physiology, and modeling chromosomal disorders. Shinohara et al. have succeeded for the first time in creating transchromosomic mice by manipulating spermatogonial stem cells (SSCs), which exhibited superior chromosomal stability compared with embryonic stem cells (ESCs).
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