Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 28, Issue 10, Pages 748-757Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2017.06.004
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Funding
- Ramon y Cajal award
- Basque Department of Industry, Tourism and Trade (Etortek)
- Department of Education [IKERTALDE IT1106-16]
- BBVA Foundation
- MINECO [SAF2016-79381-R]
- European Research Council [336343]
- FEDER
- Basque Government of Education
- Fundacion Vasca de Innovacion e Investigacion Sanitarias, BIOEF [BIO15/CA/052]
- AECC J.P. Bizkaia
- Basque Department of Health [2016111109]
- Medical Research Council [SKAG106]
- ISCIII [PI10/01484, PI13/00031]
- FERO VIII Fellowship
- MRC [MC_UU_12022/6] Funding Source: UKRI
- Medical Research Council [MC_UU_12022/6] Funding Source: researchfish
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Altered metabolism is a distinct feature of cancer cells. During transformation, the entire metabolic network is rewired to efficiently convert nutrients to biosynthetic precursors to sustain cancer cell growth and proliferation. Whilst the molecular underpinnings of this metabolic reprogramming have been described, its role in tumor progression is still under investigation. Importantly, the mitochondrion is a central actor in many of the metabolic processes that are altered in tumors. Yet, we have only begun to understand the dualities of mitochondrial function during cancer metastasis and therapy resistance. Paradoxically, mitochondrial metabolism can be both advantageous and detrimental to these processes, highlighting the need for a better understanding of the molecular and microenvironmental cues that define the role of this fascinating organelle. In this review article, we present an updated view on the different mitochondrial metabolic strategies adopted by cancer cells to overcome the many hurdles faced during tumor progression.
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