Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 28, Issue 7, Pages 497-505Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2017.03.003
Keywords
-
Categories
Funding
- National Institutes of Health [K01 DK111715]
- Pfizer, Inc.
- JPB foundation
Ask authors/readers for more resources
During insulin-resistant states such as type 2 diabetes mellitus (T2DM), insulin fails to suppress hepatic glucose production but promotes lipid synthesis leading to hyperglycemia and hypertriglyceridemia. Defining the downstream signaling pathways underlying the control of hepatic metabolism by insulin is necessary for understanding both normal physiology and the pathogenesis of metabolic disease. We summarize recent literature highlighting the importance of both hepatic and extrahepatic mechanisms in insulin regulation of liver glucose and lipid metabolism. We posit that a failure of insulin to inappropriately regulate liver metabolism during T2DM is not exclusively from an inherent defect in canonical liver insulin signaling but is instead due to a combination of hyperinsulinemia, altered substrate supply, and the input of several extrahepatic signals.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available