Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 48, Pages 15446-15450Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201709717
Keywords
cyclizations; flow electrochemistry; isoindolinones; microreactors; tandem reactions
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Funding
- Cardiff University
- Erasmus program
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Flow electrochemistry is an efficient methodology to generate radical intermediates. An electrochemical flow microreactor has been designed and manufactured to improve the efficiency of electrochemical flow reactions. With this device only little or no supporting electrolytes are needed, making processes less costly and enabling easier purification. This is demonstrated by the facile synthesis of amidyl radicals used in intramolecular hydroaminations to produce isoindolinones. The combination with inline mass spectrometry facilitates a much easier combination of chemical steps in a single flow process.
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