Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 28, Issue 5, Pages 365-376Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2017.02.007
Keywords
-
Categories
Funding
- European Commission [607310]
- BBSRC [BB/E015123/1] Funding Source: UKRI
Ask authors/readers for more resources
Mammalian neurons that produce oxytocin and vasopressin apparently evolved from an ancient cell type with both sensory and neurosecretory properties that probably linked reproductive functions to energy status and feeding behavior. Oxytocin in modern mammals is an autocrine/paracrine regulator of cell function, a systemic hormone, a neuromodulator released from axon terminals within the brain, and a 'neurohormone' that acts at receptors distant from its site of release. In the periphery oxytocin is involved in electrolyte homeostasis, gastric motility, glucose homeostasis, adipogenesis, and osteogenesis, and within the brain it is involved in food reward, food choice, and satiety. Oxytocin preferentially suppresses intake of sweet-tasting carbohydrates while improving glucose tolerance and supporting bone remodeling, making it an enticing translational target.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available