Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 28, Issue 12, Pages 831-842Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2017.10.003
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Funding
- NIDDK NIH HHS [R01 DK062388] Funding Source: Medline
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Stearoyl-coenzyme A desaturase 1 (SCD1) is a central regulator of fuel metabolism and may represent a therapeutic target to control obesity and the progression of related metabolic diseases including type 2 diabetes and hepatic steatosis. SCD1 catalyzes the synthesis of monounsaturated fatty acids (MUFAs), mainly oleate and palmitoleate, which are important in controlling weight gain in response to feeding high carbohydrate diets. In this review, we evaluate the role of SCD1 isoform in the regulation of lipid and glucose metabolism in metabolic tissues. These highlights of recent findings are aimed toward advancing our understanding of the role of SCD1 in the development of metabolic diseases, which may help evaluate the possible health outcomes of modulating MUFA levels through targeting SCD1 activity.
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