Journal
TRENDS IN CELL BIOLOGY
Volume 27, Issue 6, Pages 417-429Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2017.01.006
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Funding
- Instituut voor Innovatie door Wetenschap en Technologie (IWT)
- Kom op tegen Kanker
- FWO
- Belgian Foundation against Cancer
- Geneeskundige Stichting Koningin Elisabeth (GSKE)
- Charcot Foundation
- Interuniversity Attraction Poles program (IAP7)
- Concerted Research Actions (GOA)
- Group-ID MRP of Ghent University
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Obesity is becoming a major health concern in Western society, and medical conditions associated with obesity are grouped in the metabolic syndrome. Overnutrition activates several proinflammatory signaling pathways, leading to a condition of chronic low-grade inflammation in several metabolic tissues affecting their proper function. Nuclear factor kappa B (NF-kappa B) signaling is a crucial pathway in this process and has been studied extensively in the context of obesity and the metabolic syndrome. Here we give an overview of the molecular mechanisms behind the inflammatory function of NF-kappa B in response to overnutrition and the effect this has on several metabolic tissues.
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