Journal
TRENDS IN CELL BIOLOGY
Volume 27, Issue 3, Pages 172-188Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2016.11.003
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Funding
- NIH Common Fund in the Office of Strategic Coordination/Office of the NIH Director [U19 CA179563]
- NIH/NCI [P01 CA069246]
- Dutch Cancer Society (KWF)
- [U19 CA179514]
- [R01 GM117916]
- [R01 CA163592]
- [R01 CA206458]
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Extracellular vesicles (EVs) are a heterogeneous collection of membrane-bound carriers with complex cargoes including proteins, lipids, and nucleic acids. While the release of EVs was previously thought to be only a mechanism to discard nonfunctional cellular components, increasing evidence implicates EVs as key players in intercellular and even interorganismal communication. EVs confer stability and can direct their cargoes to specific cell types. EV cargoes also appear to act in a combinatorial manner to communicate directives to other cells. This review focuses on recent findings and knowledge gaps in the area of EV biogenesis, release, and uptake. In addition, we highlight examples whereby EV cargoes control basic cellular functions, including motility and polarization, immune responses, and development, and contribute to diseases such as cancer and neurodegeneration.
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