Journal
TRENDS IN CELL BIOLOGY
Volume 27, Issue 7, Pages 527-540Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2017.02.001
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Funding
- NICHD NIH HHS [R21 HD084959, R21 HD065089] Funding Source: Medline
- NIGMS NIH HHS [F31 GM115149, R01 GM112008, T32 GM007231] Funding Source: Medline
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Asymmetric cell division (ACD) gives rise to two daughter cells with distinct fates. ACD is widely used during development and by many types of adult stem cells during tissue homeostasis and regeneration. ACD can be regulated by extrinsic cues, such as signaling molecules, as well as by intrinsic factors, such as organelles and cortex proteins. The recent discovery of asymmetric histone inheritance during stem cell ACD has revealed another intrinsic mechanism by which ACD produces two distinct daughters. In this review we discuss these findings in the context of cell-cycle regulation, as well as other studies of ACD, to begin understanding the underlying mechanisms and biological relevance of this phenomenon.
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