Journal
TRENDS IN CELL BIOLOGY
Volume 27, Issue 8, Pages 556-567Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2017.04.001
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Funding
- Medical Research Council [MR/J001023/1]
- Wellcome Trust [105377/Z/14/Z]
- National Health and Medical Research Council [1071074]
- University of Queensland [UQECR1718865]
- National Health and Medical Research Council of Australia [1071074] Funding Source: NHMRC
- Medical Research Council [MC_PC_12009, MR/J001023/1] Funding Source: researchfish
- MRC [MR/J001023/1] Funding Source: UKRI
- Wellcome Trust [105377/Z/14/Z] Funding Source: Wellcome Trust
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Adult mammary stem cells (MaSCs) drive postnatal organogenesis and remodeling in the mammary gland, and their longevity and potential have important implications for breast cancer. However, despite intense investigation the identity, location, and differentiation potential of MaSCs remain subject to deliberation. The application of genetic lineage-tracing models, combined with quantitative 3D imaging and biophysical methods, has provided new insights into the mammary epithelial hierarchy that challenge classical definitions of MaSC potency and behaviors. We review here recent advances - discussing fundamental unresolved properties of MaSC potency, dynamics, and plasticity - and point to evolving technologies that promise to shed new light on this intractable debate. Elucidation of the physiological mammary differentiation hierarchy is paramount to understanding the complex heterogeneous breast cancer landscape.
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