Journal
TRENDS IN CELL BIOLOGY
Volume 27, Issue 2, Pages 110-125Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2016.09.010
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Funding
- NCI NIH HHS [P30 CA008748] Funding Source: Medline
- NICHD NIH HHS [T32 HD060600] Funding Source: Medline
- NINDS NIH HHS [R01 NS044385] Funding Source: Medline
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The mammalian Hedgehog (Hh) signaling pathway is required for development and for maintenance of adult stem cells, and overactivation of the pathway can cause tumorigenesis. All responses to Hh family ligands in mammals require the primary cilium, an ancient microtubule-based organelle that extends from the cell surface. Genetic studies in mice and humans have defined specific functions for cilium-associated microtubule motor proteins: they act in the construction and disassembly of the primary cilium, they control ciliary length and stability, and some have direct roles in mammalian Hh signal transduction. These studies highlight how integrated genetic and cell biological studies can define the molecular mechanisms that underlie cilium-associated health and disease.
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